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| Registros recuperados: 221 | |
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| Wan-Chung(Wan-Jiung) Hu; August Louis Bourgeois; Nathan Wolfe; Sher Singh; Anne Jedlicka; Alan Scott. |
| Using microarray analysis, we showed up-regulation of Toll-like receptors 1,2,4,7,8, NF-[kappa][BETA], TNF-[alpha], p38-MAPK and MHC molecules in human peripheral blood mononuclear cells following infection with Plasmodium falciparum. We report herein further studies based on time-course microarray analysis with a focus on malaria-induced host immunity. Results show that in early malaria; selected immunity-related genes were up-regulated including alpha, beta, and gamma interferon related genes, as well as genes of IL-15, CD36, chemokines (CXCL10, CCL2, S100A8/9, CXCL9, and CXCL11), TRAIL and IgG Fc receptors. During acute febrile malaria, up-regulated genes included alpha, beta, and gamma interferon related genes, IL-8, IL-1[beta], IL-10 downstream... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics; Immunology; Microbiology; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5930/version/1 |
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| Wanchung(Wanjiung) Hu. |
| Huntington’s disease is an inherited neurodegenerative disorder. It belongs to the polyQ accumulation disease with mutant Huntington protein. The mutant Huntington has expanded CAG triplet repeats which make it easy to accumulate. However, the exact mechanism causing Huntington’s disease pathophysiology is unknown. Here, I propose that Huntington’s disease is an autoimmune disease. During childhood, there are Treg cells from the thymus to prevent autoimmune reaction against mutant Huntington. When the patient grows older with thymus atrophy, the accumulated mutant Huntington triggers TH17 related inflammatory reaction via heat shock proteins and toll-like receptor activation. Then, TH17 related cytokines such as... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics; Immunology; Molecular Cell Biology; Neuroscience; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6129/version/1 |
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| Milind Watve; Sonam Mandani; Prajakta Belsare. |
| The adipose tissue is an active endocrine organ which secretes proinflammatory cytokines and chemokines resulting into raised serum levels. Hypercytokinemia has been interpreted as raised level of innate immunity and its evolution is interpreted as a response to increased chances of infection under starvation conditions in which the thrifty phenotype evolved. If starvation and infection challenges co-occurred during hunter gatherer life, thrifty genotype and infection resistant genotype may have co-evolved. An inherent weakness of this explanation is that in obesity or insulin resistance there is no evidence of increased resistance to infections. The raised levels of inflammatory cytokines have not been demonstrated to combat infections or enhance wound... |
| Tipo: Poster |
Palavras-chave: Ecology; Immunology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2710/version/1 |
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| Harvey Arbesman; Marian C. Arbesman. |
| The incidence of Type 1 Diabetes (T1D) has been increasing over the past 50 years. The geographical variation in the incidence of T1D varies 400 fold from a low rate in China to a very high incidence in Finland, Sardinia and Yemenite Jews in Israel. The reason behind these epidemiologic findings is unclear at this time and further elucidating the factors related to this intriguing epidemiology of T1D can help us better understand certain risk factors, the pathogenesis of the disease, and help reduce the incidence of T1D. We hypothesize that the _variation_ of the omega-3 polyunsaturated fatty acid (PUFA) content of cow’s milk and human breast milk may play a very important role in the development of Type 1 Diabetes in genetically predisposed... |
| Tipo: Manuscript |
Palavras-chave: Immunology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5876/version/1 |
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| Massó, J.A.. |
| Todos los organismos multicelulares son susceptibles a enfermedades, por lo que estos han desarrollado sistemas de defensa contra los organismos patógenos, y los peces no han sido la excepción. Su sistema inmune al igual que el resto de los vertebrados puede dividirse en dos tipos: el sistema inmune adaptativo y el sistema inmune innato. Ambos poseen componentes celulares y humorales. Dentro de los componentes humorales del sistema inmune innato se encuentran los péptidos antimicrobianos (AMPs), los cuales son típicamente de 12-50 aminoácidos con una carga neta positiva de +2 a +7. Debido a que los AMPs pueden desplegar una actividad de amplio espectro contra una gran variedad de patógenos y algunas células cancerosas, el interés de estos ha aumentado... |
| Tipo: Theses and Dissertations |
Palavras-chave: Immunology; Marine fish; Immunology; Http://aims.fao.org/aos/agrovoc/c_3808. |
| Ano: 2010 |
URL: http://hdl.handle.net/1834/3589 |
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| S.S. Soam; Feroz Khan; Bharat Bhasker; B. N. Mishra. |
| The identification of major histocompatibility complex (MHC) class-II restricted peptides is an important goal in human immunological research leading to peptide based vaccine design. These MHC class–II peptides are predominantly recognized by CD4+ T-helper cells, which when turned on, have profound immune regulatory effects. Thus, prediction of such MHC class-II binding peptides is very helpful towards epitope-based vaccine design. HLA-DR proteins were found to be associated with autoimmune diseases e.g. HLA-DRB1*0401 with rheumatoid arthritis. It is important for the treatment of autoimmune diseases to determine which peptides bind to MHC class II molecules. The experimental methods for identification of these peptides are both time consuming... |
| Tipo: Manuscript |
Palavras-chave: Immunology; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6608/version/1 |
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| Kristina M. Harris; Alessio Fasano; Dean L. Mann. |
| Celiac disease (CD) is an autoimmune disease prevalent in ~1% of the general population. CD is unique because both the major genetic (Human Leukocyte Antigen-DQ2/DQ8 alleles) and etiologic factors (dietary glutens) for susceptibility are known. While these alleles are responsible for the inappropriate T cell response that characterizes CD, they are not sufficient since most HLA-DQ2+/DQ8+ individuals exposed to glutens never develop disease. The reasons for this have not been explained; however our novel findings strongly advocate a role for interleukin-23 (IL-23) in the immunopathogenesis of CD. We demonstrate that wheat gliadin stimulates monocytes to produce significantly higher amounts of inflammatory cytokines IL-1b, IL-23, and tumor necrosis factor-a... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics; Immunology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1882/version/1 |
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| Fatena Bellahcene; Géraldine Folch; Joumana Jabado-Michaloud; Chantal Ginestoux; Patrice Duroux; Véronique Giudicelli; Marie-Paule Lefranc. |
| The immunoglobulin (IG) and T cell receptor (TR) major loci span about 6 Megabases (Mb) of the human genome on chromosomes 2, 7, 14 and 22, and 9 Mb in mouse on chromosomes 6, 12, 13, 14 and 16. There are seven major loci: three IG loci (IGH, IGK, IGL) and four TR loci (TRA, TRB, TRG, TRD), with a distinct repartition of the variable (V), diversity (D), joining (J) and constant (C) genes. The human genome comprises a total number of 608-665 IG and TR genes (371-422 IG and 237-243 TR), depending on the haplotypes, per haploid genome ^1, 2^ of which 531-588 genes are located in the major loci (distributed in 369-418 V, 32 D, 105-109 J and 25-29 C genes). There are also 77 orphons (68 IG and 9 TR) including two processed IG genes, outside the major loci. The... |
| Tipo: Poster |
Palavras-chave: Genetics & Genomics; Immunology; Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3158/version/1 |
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| Silva,Bruno Correa da; Jatobá,Adolfo; Vieira,Felipe do Nascimento; Mouriño,José Luiz Pedreira; Bolívar,Norha; Seiffert,Walter Quadros; Martins,Mauricio Laterça. |
| The aim of this study was to evaluate the immune response of hybrid surubim vaccinated by intraperitoneal injection and by immersion against Aeromonas hydrophila. Vaccine was prepared with formalin-inactivated A. hydrophila. Forty eight fishes (47±9g) were distributed in 12 tanks (4 fish / tank) in the following treatments (4 tanks / treatment): unvaccinated fish, vaccinated intraperitoneally and vaccinated by immersion. After 21 days, intraperitoneally vaccinated fishes showed the highest values of total protein and immunoglobulins, agglutination titer and serum antimicrobial activity. Lysozyme concentration in the serum was higher in the fishes vaccinated by immersion than unvaccinated fishes. Intraperitoneal vaccination induced the highest immune... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pseudoplatystoma; Aeromonas hydrophila; Vaccine; Immunology. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000100010 |
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| Jhinuk Chatterjee. |
| Investigation and experimental design of the study was basically aimed at developing insight into the antigenicity of spermatozoa-associated proteins. Apart from studying the natural antigenicity of washed whole spermatozoa, their immunogenicity was also demonstrated _in vitro_. The whole live spermatozoa were immobilized and agglutinated _in vitro_ by the antibodies they induced in the laboratory model - a female rabbit. A regular immunization routine induced a high titre of antisperm polyclonal antibodies. To prepare a spermatozoa specific antigen which will not produce a cross-reacting antibody against other human tissues, only the motile and live spermatozoa were selected for antigen preparation. In investigation the laboratory-bred female rabbits were... |
| Tipo: Manuscript |
Palavras-chave: Immunology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1855/version/1 |
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| Jhinuk Chatterjee; Sukumar Chattopadhyay. |
| Investigation and experimental design of the study was basically aimed at developing insight into the antigenicity of spermatozoa-associated proteins. Apart from studying the natural antigenicity of washed whole spermatozoa, their immunogenicity was also demonstrated _in vitro_. The whole live spermatozoa were immobilized and agglutinated _in vitro_ by the antibodies they induced in the laboratory model - a female rabbit. A regular immunization routine induced a high titre of antisperm polyclonal antibodies. To prepare a spermatozoa specific antigen which will not produce a cross-reacting antibody against other human tissues, only the motile and live spermatozoa were selected for antigen preparation. In investigation the laboratory-bred female rabbits were... |
| Tipo: Manuscript |
Palavras-chave: Immunology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1855/version/2 |
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| Soliman, M.K.; Mohamed, S.G.; El-Gohary, M.S.; Khalil, R.H.; El-Banna, S.. |
| The effect of metrifonate on the immunity of the exposed fish are evaluated through the determination of the antibody titer and mortality rate during the challenge trial. In the chronic toxic exposure to metrifonate by dose 0.17mg/liter for 8 weeks, the more clear signs were darkness of fish color with hemorrhagic patches & loosing of scale at end of the trial the color return to normal. Determination of some blood parameters revealed significant decrease of white blood cell count, as there were lymphopenia and nueutrophilia during the chronic exposure to metrifonate. Phagocytic assay revealed a significant decrease in both phagocytic activity (PA) and phagocytic index(PI).Hypoproteinami hypoglobulinaemia and hypoalbuminaemia were observed. The... |
| Tipo: Journal Contribution |
Palavras-chave: Biology; Immunology; Biology; Http://aims.fao.org/aos/agrovoc/c_925. |
| Ano: 2005 |
URL: http://hdl.handle.net/1834/1218 |
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| Bernard Friedenson. |
| Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast/ovarian cancer that are so high and apparently so selective that many mutation carriers choose to have the most likely targets for cancer surgically removed. Recent research has focused on better methods of treating such seemingly unavoidable hereditary cancers. Prevention has received much less attention so a positive test result for a cancer gene leaves carriers with very limited options. 
In order to prevent BRCA1/2 related cancers, it may be important to understand why they seem to occur only in certain characteristic organs. Results here show that mutations in a pathway depending on BRCA1/2 gene products magnify cancer risks from chronic infection and... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Genetics & Genomics; Immunology; Microbiology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4225/version/1 |
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| Registros recuperados: 221 | |
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